“Approximately 6-7% of full-time U.S. workers experienced major depression (MDD) within the past year.”

“16% of patients with major depression…do not respond to two or more antidepressants. That can cost an average of more than $17,000 per year in healthcare expenditures, compared with $9,700 among non-treatment-resistant-depression patients. Patients with no major depression had average healthcare costs of $4,700…

“Those increased expenses were driven largely by higher inpatient, outpatient and emergency department use, the study found.

“Treatment-resistant depression is estimated to cost healthcare payers between $29 billion and $48 billion annually in both direct medical expenses and lost work productivity, with treatment-resistant patients found to have lost nearly 36 work days per year per person, about six times more than patients with depression.”